New magnetic nanoparticles for theranostics: Diagnostics, drug delivery, and therapy

The first stable colloidal ferrofluid was created in 1938. The heating ability of nanoparticles in an alternating magnetic field was first used for therapeutic purposes in 1957. Ferrofluids have been included in a number of industrial applications such as encapsulation, transformer cooling, loudspeaker damping and cooling, and hazardous waste treatment. Over the past few decades, nanomaterials with sizes less than 100 nm possess unique properties in terms of high surface–volume ratios, tunable properties, enhanced thermal conductivity, which have made these nanomaterials highly useful in a wide range of applications in various fields including large-scale biomedical applications. such as targeted drug delivery, magnetic hyperthermia (MHT) treatment, MRT contrast agents, etc.. In 2000, a new method of visualizing human organs was proposed, called magnetic powder imaging (MPI). Magnetic nanoparticles (MNP) are used in the listed methods of diagnostics and treatment of humans. If at the beginning of the stages of applying the MRI and MHT methods, MNP of hematite and magnetite were used, which are the most biologically compatible with a living organism. At present, medicine, especially MPI method, requires MNP with high magnetic characteristics. 
Currently, MNP intended for use in the above-mentioned methods of diagnostics and treatment are being studied. MNPs such as core/shell: consisting of hard magnetic and soft magnetic materials, graphene oxide and ferrites, are very promising for biomedicine. The core has high magnetic characteristics, but is often toxic, so the core is coated with a biocompatible material. Combining components with completely different properties and characteristics allows us to obtain materials with new unique properties, which opens up new broad opportunities for their diverse applications. 
The report presents the work on the creation of MNP with high magnetic and structural characteristics that satisfy both the well-known MRI method and the new method of visualization and diagnostics of MPI, as well as the treatment (MHT) of human diseases.

Since 1969 A. Kamzin researches has involved to studying of the fundamental phenomena in magnetic materials. From 1990 his research programs are focused on the studding on the Biomedical applications of Magnetic and Ferroelecrtric Nanoparticles and Nanocomposites and creating new high effective composites for different applications: for biomedicine as well as for  water purification. He created new Magnetic Nanocomposites for MRI and MPI diagnostics, targeted drag delivery and Magnetic Hyperthermia Treatment of Cancer. He also created Magnetic Nanocomposites for Theranostic treatment: diagnostic + treatment. Research and Teaching Experience: 55 years. Academic Qualifications : M.Sc.(Phys.)-1970; Ph. D.-1978; Dr. of Science, Prof., Chief Researcher- 1994.