Highly sensitive and simultaneous electrochemical detection of dopamine, ascorbic acid, and uric acid using au@MOF-60 nanocomposite on screen-printed carbon electrodes

Accurate detection of dopamine (DA), ascorbic acid (AA), and uric acid (UA) is crucial for diagnosing and managing various diseases. In this study, Au@MOF-60 nanocomposites were synthesized via a solvent-based method and coated onto screen-printed carbon electrodes (SPCEs), forming Au@MOF- 60/SPCEs capable of selectively detecting DA, AA, and UA. The addition of a Nafion layer enhanced the DA signal while suppressing interference from AA and UA, enabling the nafion/Au@MOF- 60/SPCEs to function as an effective electrochemical sensor for DA. Under optimized conditions, the sensor exhibited a linear response to DA in the range of 0–10 nM, with a detection limit as low as 3.9 nM. In 10% serum samples, DA recovery reached 99%, confirming the sensor’s sensitivity and reliability. The nafion/Au@MOF-60/SPCEs also demonstrated excellent anti-interference capability, stability, reproducibility, and strong performance in real sample analysis, highlighting their potential for clinical diagnosis and health monitoring.

Dr. Rohan Sagar is a Postdoctoral Researcher in the Department of Bio-Industrial Mechatronics Engineering at National Chung Hsing University, Taiwan. His current project involves developing microfluidic electrochemical immunosensing chips for bacterial fish disease detection under Prof. Ching-Chou Wu. He received his Ph.D. in Physics from Dr. A.P.J. Abdul Kalam Technical University, India. Dr. Sagar holds one Indian patent on a CNT-GO-based ammonia gas sensor and has presented at multiple international conferences. With over 20 research publications, his expertise spans nanomaterials, polymer composites, and electrochemical sensors. He is a recipient of the UGC National Fellowship (JRF–SRF), India.